G Protein-Coupled Inwardly-Rectifying Potassium Channels (GIRK channels) are channels found in the brain that play a crucial role in thegirk inhibitory effects of neurotransmitters.
In this chapter, we describe advances in our understanding of GIRK channel function based on recent high-resolution atomic structures of inwardly rectifying K (+) channels discussed in the context of classical structure-function experiments.
G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.
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David William Donald Cameron, Baron Cameron of Chipping Norton (born 9 October 1966), is a British politician who served as Prime Minister of the United Kingdom from 2010 to 2016. After his premiership, he served as Foreign Secretary in Rishi Sunak’s government from 2023 to 2024. Cameron was Leader of the Conservative Party from 2005 to 2016. He was Leader of the Opposition f…
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